Escape from the city?, oh boy Options

[GM Lich]

So I've been thinking that just to shake things up in the city, up first I was running parts of the Denver missions. Now that I've gotten used to running shadowrun again, I was thinking of shaking things up and changing settings. I think an interesting way to do this is that runners have angered some major powers. This major power, decides he doesn't want the runners in the town, but he decides it would be entertaining to watch them run away.So I'm thinking perhaps the runners are suddenly hung up to dry, all their contacts seem to be avoiding them or not responding. So my challenges are as follows:
Where should the runners run off to?
I'm thinking a foreign country outside of the default shadowrun area, something slightly exotic for a short time until things cool down
What major power should be opposition?
My suspects right now is Ares, One of the runners took records on file Ares because he was a former military member. Also they've done some things to piss off Lone Star. It involves a helicopter crashing into some office building
Yakuza, I did run some of the Denver adventures, and they seemed to be an adversary a lot times
A Dragon, this I've been toying this idea been using this for a while
The most difficult part is figuring out how I should do this, I'm thinking of perhaps sending rating 6 grunts at them along with some prime runners, and overwhelm them,give em a clue that they have been compromised and get some advice to get out of the country asap. Of course they can cross the borders of denvers to stall but the forces will get them eventually. So I was curious have you guys done this sort of thing before. Any advice, dos or don't. Ideas for the mission