Help me with my latest one-shot!, Hunting a potent relic through the papal states! Options

[Tias]

So my gaming group has a kind of "introduce new systems" model going, where we play a new system for a couple of sessions as a one-shot.

I decided to do Shadowrun 4E the only way I know how: Fragged up chatic run where the fate of the 6th world hangs in the balance!

I know I want the team to recapture the final part of the Fátima prophecies, recently liberated from the vaticans secret archives, and now on the run somewhere in the Italian confederation.

I need exciting action scenes, but also things that showcase the mood of the setting well. I wanted a clue to be placed near a street doc, where they're tipped off by one of the many limbless chipheads littering the street. Also, a run-in with some jesuit mages, Black Madonna-style.

Still, I need some help tying it together, so I thought I'd post here and benefit from your collective psychosis wisdom! Do you have any suggestions to spice up the setting, or scenario?

So far I've written the Johnson meet on-line, and then a quick detour in a GeMiTo black mall for equipment and weapons.

It's 4E, premade 400 BP chars so I can line up the skills the encounters will need easily.