A number of years ago I tried to run a 1960s type spy campaign using SR3 rules. I had all sorts of silly rules, like there were only light pistols, and that it was not possible to reload them in combat, but instead when your pistol was empty you had to fling it at your opponent in frustration. There was also a James Bond Sexual Harassment rule that was so powerful it imploded the whole campaign.
A big part of my research was watching episodes of "The Man From UNCLE" at the Museum of Television and Radio in New York City. It's what gave me the idea for the mandatory pistol-flinging.
A few years ago 60s spy spoofs were really popular due to Austin Powers and we saw a few like-themed games emerge such as No One Lives Forever. My only recommendation if anyone wants to run a spy campaign today set in the 60s is that they must watch a few episodes of "The Man From UNCLE" which are, again, available at the Museum of Television and Radio in New York City.
Wikipedia entry: http://en.wikipedia.org/wiki/The_Man_From_UNCLE