One of my PC's wandered out in Seattle, Redmond Barrers, when the other team members were busy with stuf, not related to the run.
Me: So, were are you going?
Player: Just walking around, do I see something I recognise?
Me: Are you going anywhere special?
Player: No, not really.
Me: [Describe hooker encounter]
Player: Walks one, no interest.
Me: A man grabs your shoulder, and tries to sell you a watch, for 10

Player: I push the man away.
Me: the man falls on the ground, and starts cursing you for all he's worth
Player: I turn off my cyberears, so I don't hear him anymore.
`Mind you this PC has totaly tricked out cyberears, including soundfilters`
Me: Make an audio perception roll at -6 (he's deaf atm)
Player: Looks at me unbelieving. makes the roll and fails the treshold. (PC has a dice pool of 13 for perception)
Me: As you are walking down the street, deaf for all purposes, you feel a claw strike you on your back (I make an attack roll, and tell the player to roll for damage resistance)
Me: Next your are hit on your shoulder by a claw. (I make an attack roll, and tell the player to roll for damage resistance)
You are attacked by two ghouls and no the others can't make it in time.
Player (after a few hits): I take a flashpack ( he is in melee) and throw it to the ghouls, close my eyes and runaway.
I was very lenient that session.