-- First off, go buy
Spacecraft of the Solar System and
Under Pressure pronto
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-- More seriously, if you are having a problem figuring out what your characters do (beyond shadowrunning with bioroids instead of elves) I suggest
Personnel Files which has many pregen characters and groups with ready-made background stories and plot hooks.
-- All the TS books are high quality, with the notable exception of the adventure
Orbital Decay -- which was a generic zombie horror adventure "parachuted in" to the game line without much (read: any) input from the line developer or other authors.
-- For space-based games I recommend
Deep Beyond as it's chock full of wierdness and
In The Well. For earth-based games I recommend
Broken Dreams and
Fifth Wave.
Broken Dreams in particular is ideal for playing games that are recognizable to the players (as "Third Wavers" while still having access to the wierder "Fifth Wave" technologies and social constructs.
--
Toxic Memes is good (it has a big selection of wierd ideas, cults and concepts), although I do think it goes a bit crazy with "memes as mind control" which was not the intent of those rules.
--
Under Pressure has the most complete set of aquatic adventuring material in any RPG that I'm aware of (certainly more then even Blue Planet) and is a much darker view of the optimistic outlook from
Fifth Wave and the core book (at least regarding the environment). Lot of interesting research went into that book, heck it's referenced in a Phd thesis (seriously)! I'm one of the writers so I'm biased as hell
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--
In The Well presents the "default" extraterrestrial gaming area (a partly terraformed Mars) and plays up a bit of the wuxia elements of the setting.
--
High Frontier has a perfect campaign setup with the "vacuum cleaner" debris teams.
-- Most of the books are setting, although a few do have some GURPS crunch (the modular design systems primarily). GURPS handles the character types more readily then most game systems so it might be worth and least downloading the free GURPS Lite: Transhuman edition from SJG to get a feel for the rules.
-- The official TS website sucks monkey nads. I've tried for YEARS to get SJG moving with a decent web presence to no avail (I am/was the official volunteer coordinator for the TS webpage BTW). I finally said "screw it" and made my own page that's still more current then the official one despite the fact I haven't touched it in a while while working on 4e stuff.
http://matrix.dumpshock.com/tzeentch/Transhuman/-- To get in the TS "groove" I suggest watching GitS: Stand Alone Complex and PLANETES. GitS in particular is a BIG influence for TS. See my bibliography page for an extensive list of references culled from all the books and some new additions.
-- Also check out the Yahoogroup "transhuman_space" for interesting conversations.