OK, so a quick look through the toxins section shows that there are a number of ways to be completely immune to various delivery methods of getting toxins to you. If you have, for example, a complete Chem Seal, then you're pretty much fine so long as noone tricks you into drinking a rooficolada. But short of that, what exactly are you supposed to do?
Bonuses to your toxin resistance from sources which do not give you actual immunity just give you extra dice - which means that rating 3 (a 60,000 investment on a toxin extractor) on average reduces the power of a toxin by 1. And since Narcoject has a power of ten, that's basically meaningless.
In older versions of Shadowrun, protective gear and Blood Filtration reduced the power of toxins. In SR4, it takes three levels of Protective Gear to achieve the same effect. So as near as I can figure it, protective gear that doesn't provide actual immunity is a waste of your time. You can walk in with no chemical awareness at all, and it takes two squirts from a narcoject delivery system to drop you. And you can get bleeding ede Toxin Extractors and Chemical Protection, and 2 Narcoject squirts are still going to drop you.
What gives? And for that matter, why isn't Blood Filtration in the basic book anymore?
-Frank