I see that Kamikaze causes an automatic wound which damages implants, but what about on someone with no 'ware? What are the negative effects other than addiction? Sure Spirit's Strength is more practical... just wondering about the chemicals at the moment.

And where are the rules on drug use interacting with magic? I have been poking around MM (p119ish) and haven't come across any yet, though I am sure there have got to be some.

Yeah, its wickedly addictive, and that can lead to magic loss.

Drugs stack with everything. They just are expensive, and very easy to kill your charcter in the long run with.