My concept is that the players are all patients in a private hospital of the Draconis Institute (think a combination of the Bureau of Paranormal Research from Hellboy and the Hoffman Institute from Dark Matter). They are suffering from a relatively new and rare psycological phenomenon called TRDS or Temporal Regression Syndrome. This is a concept I put together specifically for the change between setting and system using the same base characters. The shadowrun characters' minds have started to react to the mass stimulation and advancements of technology and such prevelant in the world of 2070 in such a way that their mind creates an alternate world that more resembles our own time as well as certain other dillusions. These delusions have them imagining they are awakened beings in 2005 Cleveland, OH USA. (A mage and two werewolves).
The insitute is especially interested in the PCs because of the patients they've treated for TRDS, these three are the only ones to have interacted with the same delusional world (even though they are strangers outside of the delusion). The Insitute plans on experimenting with this odd connection they seem to share in a shadowrunning capacity and see if it can be exploited. The characters will start with amnesia and only have memories of the delusions that they encountered their TRDS. The characters from the World of Darkness game (and thus their delusions) will be converted to NPCs and contacts. As my players are fairly competant RPers it should be a fun experience.
Feel free to post your own opinions, advice, suggestions, hate mail, etc etc.
