I tried this on another thread but maybe it deserves it's own dedicated one.

Trying to think of good NPC handles isn't always easy. To create a useful resource, please submit the best 5 handles you've encountered (even if you made them up yourself). Then we can all have good names for our supporting cast. If you like, you can give a brief description, but it's the cool names I'm after.

I'll submit:

Catalyst: a fixer who gets things together.
Cinnamon: gillette.

Chessy as hell but..
Justin Case - Bodyguard
Ryan O'Brian - Cyclops

Bounce- Rigger

Boy did that handle make the PC's nervous when they hired him as a wheel-man.

I'll think of some more after work.

DeRez- Matrix contact whose just a tad off

Lazarus- Street Doc who heals you the best

Jimmy The Nose- Fixer who gots his nose in everybodies business

The Nose - a blogger who somehow finds out about alot of the unknown going on's in the city. 'The Nose knows...'

Dr Fore Gitfall - A Street Doc who has trouble finding glasses who are on his head or other things that are usually in easy reach. Forgets the character's names during conversations.

Zero Friction - A rigger who is known for his erattic driving, even during normal situations. Likes to power slide through corners.

Radar O'Reilly - a fixer who has the errie ability to answer his commlink and talk about whatever the character was going to ask about before the character actually does.

Glitch - A rigger who is actually quite good at his job

Judas - a nice guy, really... looking for a few good 'runners...

Doctor Anton Pocovitch, AKA Doc Apoc, former Biogene researcher,now working as a street doc

Razor and Blade! -- "They're E-l33t!"

Meat - All those goons that the PCs blow away. "Meat is meat, learn to eat!" - Fairy Meat

Lillian - Decker with a spider fetish
T-Rex - Decker with a T rex icon
Mokole
Jin
Whisper - Owl Shamen
Vixen
Silver
Falcon
Jackknife
Darkside
Edward Spotted Horse - Eagle totemic adept/ Sioux brave

Möbius, a generic fixer so ill-conceived you might call him one sided...

Ripperjack - heavly chromed sammie stolen from CP2000
Wrench- often called Monkey when he makes a mistake
J.J aka Jumping Jax- Combat decker turned fixer
Winter Eyes
Attradies

Zapper - a young young street mage
Midnight
Gun
Serif
Gabriel

Well, speaking of cliche names but ones that I just can't get away from, there was a rigger and gunner team of NPCs in a campaign I ran called crash and burn. Through some rather silly actions on the part of the PCs, their helicopter actually did eventually crash.

...Chief Headless Chicken [Bounty hunter Jill's Tribal Chieftan Contact]
...Sam I Am ["universal" fixer for most of my PCs]

...Smeg
...Nasty
...Reg
...Scrump

[Members of an oppos runner team named the "Pre Fab Four" (UK)]

...Happy Nat [another Fixer]
...The Mad Irishman [Decker/Hacker who survived the crash AKA "Harper"]
...Sterling Steele [one really bad ass lady, who'd sell her own mum down the tracks]
..."Mr Heath" [Johnson (UK)]
...Smoker [Night Angel's CIA contact]
...Crazy Ivan [Russian Pyro Mage - the name says it all]
...Lt Z [short for Zanaczeck - Serbian SSID "interrogation specialist"]

Mad Max (with his bodyguard Humangus) - BTL ripper and designer
Skids - Rigger

The ones I had that really worked were more for the personality I think then the names but now everytime I or my players say that name we think of good times. Anyways mine go:

Wired Wolf - a wannabe Adept street sam that eventually became a mentor for some of my more tactically challenged PCs.

Bricktop - origonally a sterotypical dwarf rigger who ended up being considered a member of the team. Name comes from the fact that he always make sure all sides (including the top) of his vehicles are well armored.

Rockin Petey - a street sam with gyromount cyberarms that loved to shoot things up. The players came to love him as he was just all about a good time and was a nice contrast.

Slice 'n Dice - an extremely talented decker with a jack the ripper fetish and a tendancy to kill people. He started as an object lesson that while any given runner may be great to work with they may not be great people or even people you want to admit to knowing. What really got the PCs to like him is I styled his real life personality after a friend of ours named Bob who we call Silent Bob because the dude doesn't talk and I styled his Matrix persona on a buddy we call "The Mouth" because he's always talking and incredibly out going. Favorite quote from one of the PCs that knew Slice to one that didn't was "If you make him talk anymore he's going to spend the next three days cutting you into small bite size pieces"

My most recent Johnson I have introduced into a game is a 'Mr. Johnson' wearing horn rimmed glasses.....

There are five things that, if done by a Johnson, indicate that you should calmly shoot him in the face until he is dead and leave.

They are:
Introduces himself as "Mr. Johnson."
Uses the word "dragon" in a sentence.
Requests that you sign a physical contract rather than relying on a digital signature. (This goes double if his only pen uses human blood instead of ink.)
Tells you that, no matter what happens, you must not open the case.
Wears Horn-Rimmed Glasses.


Paladin - A well-educated pistol adept with a heavily customized six shooter who, ironically, is completely amoral and would shoot a baby in a stroller if the price was right.

Fat Samurai - A gluttonous burn-out adept who had extra cyberarms installed (in addition to his flesh arms instead of replacing them) so that he'd be able to eat and kill things at the same time.

Mr. Wizard - An full hermetic magician who has no first name.

Phantasm - Actually a group of runners pretending to be a single individual. The ability to accomplish jobs on opposite sides of the planet at the same time give credence to rumors that he is a ghost or a free spirit.

Spaceman - Has never actually been to space.

Junkyard - A fence specialized in used goods.

Gizmo - An ex-corpo engineer recycled as a street inventor.

Unhappy Max

I was in a group once that used the Zodiac for names. It led to one guy who was apparently keeping a body count proclaiming, "I've killed more people than Cancer."

Esper - street mage contact
Sunny on the Spot - Fixer
Johnny Hardcore - Razor boy
MITnick - Hacker
MR. Smythe - International Fixer

Loki - Elven Face & Phys Adept
Sphinx - Dwarven combat decker
Rahab - Elven Black Mage (Nicknamed "Book Wurm")
Toto - Troll Phys Adept

Billy the Goat - Fixer
Trojan - Blogger
Sharky - Bookie
Titan - Trog Gang Leader
Bruno - Ork Bodyguard
Danny Boy - Fixer

Sultan - luxury loving cat shaman

OMFWOG - Troll demolitions expert and heavy weapons specialist. Stands for "Often Mistaken For Wrath Of God"

Wiggy - Ginger haired teenage troll shaman with Logic 1. "No Wiggy - Not the Hellblastl!"

Tux - Ballroom dancing, ex-ganger samurai. Tagline: "I can kill people AND dance!"

Ice - NPC assassin. Elf, nothing less than betaware, by the book killer. Also known as "Roll surprise... you're dead."

My personal favorite is one I stole from Fallout 2. A street doc named "Painless" Doc Johnson. The reason he's painless is because most people pass out from the pain before he's done.

I called the one-shot street samurai out of the SR3 main book Jack D'Rip and he mopped the floor with those damn gangers from the Food Fight module.

I had a rigger who was blind named Black Eyed Tom.

Polar Bear - An arms dealer who always had the AC down to 50 degrees or lower.

I had some extra bodies to fill up the roster called Meat Boy and Dead Meat in Japanese.

Big Balled Billy - An orc decker with an axe to grind about his "package" size.

Ratchaser: Cat Shaman
Roger Ramjet: Amerind Rigger (stolen from NAN 1...I think.)
Greymaulkin: dwarf weaponmaster and fixer.
Andrew Marks: sniper street sam
Michael "Pierce": wolfshaman
and personal all time favorite. Created by a PC is... Billy billy Camel: a fixer, pharmacist from india.

The Balled Avenger (works best in a purely oral game)

The best small go-gang ever:

James "Fox" McCloud
John "Falco" Lombardi
Erin "Slippy" Toad
Peter "Peppy" Harington

And don't forget the Rigger running Battle Tac from the Semi behind them: Rob "64 Bits"

My favorite NPCs from way back when I still GMed Shadowrun:

Trollkien - a teenage prodigy who goblinized into a Troll just after his first sci-fi novel made the best-seller list. After the change, he found he just couldn't hack it as a writer anymore (editors just won't take him seriously) and now he's a bitter old (for a troll) man who gets by on occasional bodyguard contracts. His handle is a play on the name of his childhood hero.

Sarge - Imagine the drill sergeant from Full Metal Jacket, but as a dwarf.

One from a friend's game:
Troll: Fluffy... the Destroyer of Worlds.