Once, a group of shadowrunners (I was GM) was hired by a UN Johnson and sent to Swaziland to rescue a WHO doctor who was stranded in the jungle and captured by unknown parties The meet was in Geneva and half of the run was getting from Cape Town to the midst of an Awakened Jungle.
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The doctor was in charge of a WHO mission, on their command they had left their assigned area to help some villagers south in what it seemed an unexplained Ebola + outbreak. When the UN party got there they discovered that the outbreak had been caused by a secret Uni Omni project that had gone wrong -or not- infecting the villagers. The UN group was then murdered by UniOmni operatives. UniOmni spared the doctor because she was kind of an eminence and forced her work for the corporation instead.
and...
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The runners got there, discovered all this and successfully rescued the doctor while getting infected with the virus. The trip back to the civilization turned out a race against the clock to get to any medical facility before Ebola killed them.
also...
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...I did not mention the raiding warlords who had armed forced fighting a guerrilla in the area or the plague-ridden villages, or the toxic spirits of man that the desolation had awakened. Tough run, that one.
and imagine the player's surprise when they discovered that...
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The final twist was that the african UN Johnson heard the runners report, had them set in a hospital there, reported back to the UN, chalked up the mission as failed ["everybody died under medical care" ] and sold the Doctor and the hospitalized, virus infected runners to Yakashima. -think aliens 3-
The runners, half infected, had to escape from the hospital and from Yakashima security.
They runners survived and rescued the doctor again. They had no means to return from Africa and so had to stay there laying low and getting cured until they got to their feet and started plotting revenge. They had no money and ended up returning to UCAS in a cargo freighter they pirated and sold to pay for expenses. They finally ended up killing Mr. Johnson. They kidnapped him, infected him with the virus and locked him in a ship's cargo hold until he bled out. The doctor got zeroed and became a street doc, she is currently living in Tenochtitlán (!) with her adopted child Mbele, a kid she had rescued from the diseased village.