Here are a few questions I thought about. Some I answered for my own campaign already, some I am still undecided. I am sure others have similar questions and answers.
1. In a time where money buys beauty, who is ugly still? How accepted is ugliness in society? How much of peer pressure drives people to invest lots of money in cosmetic surgery to become more attractive? Given how good looks are so desirable in both the work and the social life, are just the squatters who cannot afford it ugly, and everyone else buys some beauty? Or does the VR/AR proliferation make it less important how your meat body looks, since you work in VR, and party in VR, and live in AR?
2. How are mages doing for relations? Given that mages can discern a lot, especially emotions, through assensing, how many are in relationships? How many are astrally active during intimate moments, and know at once if the partner doesn't feel the same? How many mages, how many of their partners can cope with this? Even the temptation to check if your partner really loves you must be great, as must be the fear that you're spied on, or even manipulated magically for the mundane partner. How many mages actually seek love in the one place where they cannot check, but have to trust a partner, in the matrix?
3. Mood chips/partial personafixes. How many people slot them just to be perky and friendly 9-5 in their job? And how many never take them out, unless to replace them with some other emotion? How many even slot chips just to feel love, keep loving their partner? Would anyone even advocate this, to keep a relationship stable, and prevent say child abuse out of frustration? Would locked mood chips be a legal punishment for violent criminals, keeping them non-violent and happy?