shadowrun: (insert sprawl name) do it like a combo between grandtheft auto and mass effect....a character design system with all the races and options based on the sr4 rules and a twitch based combat system influenced by the stats (like mass effect). IE more unarmed=/faster/deadlier/more varied moves, higher rifle grants a smaller reticule etc.. It should have a dialouge system like mass effect/kotor/nwn with multiple options allowing you to befreind and antagonize multiple factions. there should be a main campaign with a whole bunch of little side campaigns and quests.
shadowrun: totalwar. Part of the total war series players can take on the role of any north american nation and try their hand at conquest in turn based strategy and real time tactical gameplay. The player must keep corporations happy as they depend on them for most of their trade income. A major difference between this and other games would be the more detailed espionage system where the player assembles a team of "shadowrunners" to create a team unit with stats equal to the runners abilities.