Well. Damn. This is a challenge. In order to be effective, with spirits, wared-up sammies, and adepts as your opponents, you're going to need dice pools to be competitive. Fortunately, we've a few tricks up our sleeves.
1) Initiative Passes. No matter how you break it down, you need more than one pass.
How To: Some flavors of Infected, such as goblins. Drugs like Cram and Jazz.
2) Going First so you don't Die First.
How to: Edge to go first. Adrenaline Surge quality to do that automatically at combat start.
3) Not Dying. You're going to need a high reaction. With some Martial Arts tricks, we can turn your defensive dice pool into an offensive one.
Ways to achieve this: Genetic Heritage(Genetic Optimization: reaction) for one point nore than it would be normally. Reakt EPE. Lightning Reflexes quality adds +2 to reaction, AND uses the Augmented values, but doesn't stack with ware or magic.
4) Edge. Lets face it. You're going to need it. Play a human, get lucky, max it. Or get lucky anyway, and max it.
how to: Way to many build points, and review how it may be used. To go first, to take another pass, to pre-emptively add edge dice to a test and rule of six them all, to post-emptively add the edge dice only with rule of six, or reroll nonhits.
5) Effective dice pools. Since you're going to want to be effective in whatever you do, you're going to want to roll high, but still roll enough dice to not suck.
How to: Specialize Everything. Focus on High stats. Pick a metatype - their expanded natural maximums are going to make a difference. Consider going Troll or Dwarf.
6) Making up for the difference. You're going to need a lot of gear. Fortunately, gear can replicate almost any cyber-ability. So you're going to want to have the toys to make up the difference for you.
How to: Restricted Gear: milspec armor. Restricted gear: agent 6. Restricted Gear: Tacnet 4(smartlink pilot upgrade your guns. Stick a sensor upgraded iball in your pocket. Have some dobermen on standby.) Get a good PAN setup. Good commlink, good firewall. Glasses or goggles with Thermo/Flarecomp at least, and earbuds with dampening minimum. Make sure you're not valuable, precious dice due to Vision Penalties. Get a Reach 2 melee weapon. the dice makes a difference. Electricity damage owns everything. Get stungloves and sticknshocks. Don't be afraid to use smoke and chemtech to your advantage - especially when it won't affect you, due to chemical sealed armor or properly configured vision mods. Armor Helmets are -surprisingly- useful with their capacity, even the one on the Urban Explorer. Personal ultrawideband radar? Yes please.
7) You Know Kung Fu. Martial arts can be used to increase your effectiveness in a variety of areas, from +infiltration from ninjutsu, to Krav Maga's Take Aim as a free action - which you're going to be using a lot with Vision Magnification to ignore range penalties.
How to: Maneuvers. Disarm, Setup, Finishing move are all nice. Multistrike is -surprisingly- useful, because Melee attacks may simply split their dice pool to attack multiple targets within range - combined with things that add to a specific test(and not the dice pool), like a specialization(+2), tacnet(+1-4) and Personalized Grip(+1) that extra +1 dice from multistrike suddenly becomes Free Lunch. Iajutsu can let you quickdraw -anything-(like grenades.) Clinch lets you get rid of someone elses reach bonuses(stupid trolls with long weapons). Full Offense is amazing for a Gunfighter, because it still lets you defend against range attacks.

Qualities. Hit up the Runner's Companion. Any quality that improves skills and uses augmented values (College education, trustworthy, catlike, etc) is worth considering. Think about Astral Sight. If you're really set on not getting any Ware, the ability to astrally percieve is -invaluable-. And, more importantly, will help you sneak past awakened threats. Assensing is awesome, astral projection is icing on the cake, and being able to take astral combat skills is useful(Attacks of Will are Willpower+Banishing, remember?)
9) Consider going Rigger as a side-job. You don't need a lot to do it. Good Command, decent commlink, and a VR-unit with trodes lets you do a decent enough job, and drones are potent and disposable backup that also contribute to your tacnet.