Hardboiled mixes extremely well with cyberpunk. Replace "negro" with "troll", "spic" with "ork" and "rich dandy" with "elf" (and/or mage).

I have written an article about that, but it's in French. You can find it
here.
To sum it up:
Setting: economic crisis, rise of crime, violence and immorality, big divide between rich and poor. Nothing to adjust here.
Atmosphere: it's a harsh reality out there. You don't downplay it, but you don't stress it either. You should tell the story with a simple and direct language, have the NPC talk with the street language (except for the higher class). Even combat should be simple, brutal and direct: no acrobatics and style, just a few cahotic seconds, a few shots, and one side is left standing.
Characters: Mooks are stereotypical but main characters are more complex and realistic. All characters try to get by in an hostile society. They can try to escape with drugs, gambling, sex or any other mean. They can try to shield themselves, becoming violent to prove to themselves that they are tough guys. They can try to get higher on the social ladder or cling to some values. They'll often group themselves with people who share the same race/belief/social group, isolated from the outside world. The main idea is that, by trying to get away from the world's darkness, they fall into it. Because of that, most if not all Noir character will have something to hide.
Scenario: A Noir scenario is complex. It often starts with a simple event which leads to an investigation (a murder, blackmailing...) which leads in turn to something bigger. The story behind it all might be simple, but the problem is that every person involved has something to hide. As the story goes on, some of these people turn up dead, and the things that everyone wanted to hide start getting unveiled, revealing the worst things metahumanity has to offer. Most of the time, the characters aren't leading the story forward: the story happens around them, and they do what they can and so do everyone else. Most of the time, by the end of the story the truth is known but it doesn't matter anymore since everyone was destroyed in the process.
PCs: The biggest problem with a hardboiled Shadowrun game is that PC aren't necessarily hardboiled heroes who drink whisky and hide their emotions behind a mask of toughness. They might also be too strong to get beaten up correctly by mooks. If you want them to get along, a good thing is to ask them how they manage to survive emtionnaly in this rotten world and to have them realize that they don't just live there, but are forced to take part in it.