I was thinking this very thing not so long ago...
Equipment (Particularly Cybernetics and Bioware) would be very different in availability and general usage. Cyberlimbs might get you a second look, but Cyberoptics and DataJacks wouldn't. Almost anything else is MilSpec and usually isn't seen by John Q. Wageslave or Johnny Ultraviolent the Pink-Mohawked Punk. The rest is available as shown in the sourcebooks, with "Old" equipment mentioned in the Fluff also available, and new stuff coming out as the years pass by.
The rules for Hacking becoming Decking by just having CommLinks exchanged for the prices of their equivalent Cyberdecks in SR1/2, and, yes Virginia, it is all wired again. Oh, and you better be prepared to pay through the nose for Data Storage! Optical memory isn't cheap enough to put into anything and everything, and you need to buy what accounts to portable hard drives and fingertip-sized Optical Chips.
Due to the Balkanization of North America and The Crash, the Cell Phone Network was ripped apart and is just coming back into existence, so Cell Phones are just coming back into vogue (Think the Mid-90s, only with better cell phones.). The culture has gone into a Retro-1980s look, with "Thug" being the "Wiz" thing at the moment (The first Terminator.), and "Tribal" motifs are very popular as well, sometimes combining the two into "Urban Tribal" styling that is popular with Shadowrunners and Shadowrunner-Wannabes.
Racism is still heavily apparent and apparently, with crosses burning to illuminate hooded Humanis members, and burning Humanis members illuminating Sons of Sauron. Infrastructure is still recovering from The Crash, and only the rich can rely on any essential services aside from the fire department and garbage collection. In the Middle-Class, Buildings are either newly built and in semi-OK condition (Aside from being built cheaply and corruptly by Mob- Connected Construction Companies, but out of newer, tougher material), or are older buildings that are falling apart. Lower-Class and Barrens just have old buildings, with the Barrens never receiving any new construction.
CredSticks come in various flavors, including the Registered CredStick, which is your wallet, your ID, and probably your car and house keys. Cash

is still around in various forms, with Certified CredSticks being an option as well. Countries still print their own money (But I run it that way in 2070 as well.),
Data Trails (At least when it comes to purchases and such) are much harder to track, which makes SINs last longer, but they're also more expensive as Crash 2.0 and SIN Amnesty hasn't happened yet to open holes in the SIN network. However, you can actually live without a SIN as long as you stay away from higher-end stores and "random" police/security ID checks.
The big mob groups are still around, with the Vory and Triads starting to make headway into Seattle's Mafia and Yakuza heavy groups. The AmerInadian "Mob" is only a rumor, but one that's believed to exist because, well, Las Vegas.

Beer is synthetic, coffee is mostly made of soy, and old folks aren't complaining about how bad things have gotten from the "Old Days", but complimenting on how good things are turning out. This should tell you something.