But Agents have a Pilot rating and Autosofts, as well; yet they're not *drone* Pilots. AFAIK, they can't Jump In. Sprites also are *not* OS, which drone Pilots are. …But sprites get both agent and drone autosofts, right? So we're clearly dealing with a number of distinct things, and I'm just saying it'd be nice to get it all straight. AFAIK, the rules don't explain this.
So:
Hackers can Jump In (hardware-mediated VR; simsense).
Technomancers can Jump In (wetware-mediated VR; simsense).
Metasapients with Piloting Origin can Jump In ('natural').
Vehicles Pilots are 'naturally' Jumped In? (In a sense, this is identical to a Piloting Origin metasapient, except they're device-specific).
Agents cannot Jump In (AFAIK); can they Command? I feel like we've have debates about this, and it was 'no'.
Sprites ?

I think the very best possible answer is that *some* Sprites can Jump In, while others can't. Sprites are different and special, and their abilities should (but don't really) express that.
I find the suggestion that something (maybe Sprites) can drive a vehicle on 'manual' (non-VR driving) very interesting, but we'd want some theory to integrate that option. I've never liked that Command does everything for everything. :/