QUOTE (Tymeaus Jalynsfein @ Aug 18 2013, 08:43 PM)

But that is exactly what you use a PAB for. How else are you going to program a deep cover agent? In the Shadowrun World, you use a PAB for that.

YMMV. In that instance, you're starting with someone who already has a mind, and then sculpting it to order. FuelDrop is talking about taking a "blank" brain and writing to it like a hard drive. How would biofeedback work on a brain that, by definition, has no responses to alter?
QUOTE (FuelDrop @ Aug 18 2013, 08:44 PM)

Could you find someone with a personality close to what you want, use PAB to fine tune them,
Easily.
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then copy their personality and put it wholesale into your creations?
GM fiat. I would say no. AFAIK there has never been any sign of Shadowrun having the technology to copy a mind.
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Would such a creation have a soul, or be able to function without one? If they could, then theoretically this concept might be able to break the cyberzombie barrier.
Again, GM fiat, but for reasons of game balance your GM would have to be completely off his rocker to allow this. Cyberzombies with positive Essence, so you can shove even more 'ware into them? No.