Yeah it is a bit of a juggling act, though I would say Reaction enhancers do NOT work with the Move by wire as the MBW sort of keeps the body in an ongoing seizure, but one can debate it.
Edit source question, had forgotten there was a 4th ed version.. I went with a more old school approach

Rumours abound of a new Move-By-Wireless (WMBL) system being field tested by some certain parties.
Building on the original MBW system(Cybertechnology style), they have worked out some of the kinks by utilizing the constant uplink to the Matrix to help keep the constant fly by wiring of the nervous system more balanced along with advances in the overall system have made it a bit more body system friendly. It is incompatible with all other enhancements to Reaction, including wired reflexes and Reaction enhancers.
Wireless Bonus: Well, considering the whole thing is built to be run wireless the stats for the system are the bonus and yes some of the bonuses WILL exceed the normal +4 limit.
Again, THIS SYSTEM WILL NOT PROVIDE ANY OF THE FOLLOWING BONUSES AT ALL IF SWITCHED TO OFFLINE.
Get a decent firewall on the commlink or a decker buddy.
[Why the all wireless route? While originally more as a joke it does have some merits: One, to throw this into the deep end of the wireless pool, you can not wade around offline. Two, in this case it sort of makes sense seeing as the MBWL is using the Matrix to keep it altogether]
Level 1: +1 Agility +2 Reaction and +1d6 Iniative +1 dice for skill tests from the Athletics skill group. Essence: 2.15 Cost: 125,000
Level 2: +2 Agility +4 Reaction and +2d6 Iniative +2 dice for skill tests from the Athletics skill group. Essence: 3.35 Cost: 250,000
Level 3: +3 Agility +6 Reaction and +3d6 Iniative +3 dice for skill tests from the Athletics skill group. Essence: 4.55 Cost: 625,000
Level 4: +4 Agility +8 Reaction and +4d6 Iniative +4 dice for skill tests from the Athletics skill group. Essence: 5.75 Cost: 1,500,000
[Think this was a good translation and yes it is a bit pricey, but you get what you pay for with all the perks]Device Rating is considered to be Rating 1 per Level and has 4 levels of noise reduction built in.
Note each level of noise over the ability of noise reduction to reduce will reduce effective level of system performance by one.
[Yes most devices are either working or not due to Noise, but I thought the gradual degradation was more fitting in this case]Example: Jimmy 'Speedy' Rodriguez has a Rating 2 Move By Wireless system. Normally he enjoys the +2 Agility, +4 Reaction and +2d6 Initiative but today he is going to a little black market electronics event on the edge of the sprawl where anything and everything is going up for sale. The Noise from the sheer density of all the odds and ends electronics and other devices is creating a level 5 Noise rating. Jimmy gets 4 levels of Noise reduction from the system, but the remaining point of Noise sends the system skittering a bit and now his effective bonuses are just that of a level 1 system. Now Jimmy is having some shakes as he isn't moving as smoothly as he should.
If the Noise around Jimmy climbs to 6 or more its bye bye bonuses as normal for any device being jammed by Noise vs Rating. The only difference here is the system degrades as the noise climbs since it is pretty tightly wound and even small errors creeping in tend to snowball a bit.
As to Long Term effects, there are case studies showing some neurological and muscular damage over time, the body simply can not handle being in a constant state of seizure, the incessant wear and tear takes it's toll both mentally and physically.
Worse is the fact the system seems to be addicting as the test subjects grow to enjoy the jazzed up feeling and they have shown signs of resentment when forced to turn the system off and will turn it back on at the earliest possible opportunity, even when informed of the destructive side effects from prolonged usage....
Addiction Rating equal to 4 plus Level of System, Addiction Threshold 2.
[Why would anyone want to use something that could kill them or at least wreck them over time? Because it comes back to everything has a price and this is a bit like riding an electric tiger, nerves all a jangle as you tear through the opposition as a blur.]It does look odd I admit, but it has to be different enough or why not stick to vanilla wired?