Yeah there are a ton of ways for people to get around it on the physical
However with that said.
It starts like any normal run. A call from a fixer, a meet with a Johnson, a job offered and cred negotiated. Only this is an extraction with a difference. You're going to get back a lover or fiance or a spouse who's run off with someone else, which is kinda weird for a run. Making it more weird it's not just one but several, the Johnson was a face man for a group of people (community, employees, neighborhood) where significant others have been going missing. Not in a sudden way, but people leaving in obvious fashions with no one really knowing where they've been going, bit it's odd enough for the group to look for help. They tried the 'Star but that has been a week now and nothing and the (local corp sec for the community if they have one) are also no good, due to territorial issues. So they've come looking for outside help.
The investigation by the runners IDs a few common threads, leads to a couple of small scuffles and links all the absent people to a single person. Who happens to own a rather opulent residence and employs some private security. Once the runners have got through all they they may notice some of the weird magic in the area, a bit of background count etc. The person responsible is a Toxic Shaman with Seductress Totem and has been whisking people away from their loved ones and making them into, for all intents and purposes, dolls and toys. The final confrontation comes down in a labyrinth of mirrors (one of the favourite play places for the dolls) with the extraction targets occupying parts of the labyrinth as well as the shaman in there. So you have images in mirrors of the extraction targets, the shaman (who will be able to change appearance with illusion magic) and the runners, meaning UltraSound is less reliable. Give the shaman some Masking, throw in some wards, add a few toxic spirits Astrally and tag a few spells about the place and you have a challenge.
Spotting the reflections etc comes down to using Observe In Detail (TN modified by things like UltraSound etc) to work out where mirrors are with more successes require to ID threat or non-threat successfully before taking an attack action. Astrally it's going to come down to assensing targets in much the same way. In both cases you have to be real careful to pay attention to the sensory information you have to NOT shoot/stab/manabolt extraction targets.
Conversely the hall of mirrors motif works very well for Matrix Runs especially if they stumble into a UV host and for Metaplane quest stuff too.