So, I recently finished Harry Turtledove's The Case of the Toxic Spell Dump.
The major concern is that certain magical by-products are harmful to the environment, and the people living there. What a wonderful idea!
Imagine, if you will, a government-licensed corporation which created heavily-warded areas where other corporations could (after properly decontaminating the materials) dispose of their harmful magical waste for a price!
The possible contaminants in the SR universe abound: poisonous alchemical byproducts, items subject to extensive spell testing, bound spirits, certain paranormal critters, FAB experiments, etc. Basically, anything that could create a background count or mana warp.
Shadowruns in such a magically toxic (and heavily-warded) environment would be excellent...a corp might want to know what a rival corp is doing, and seeing what they're dumping could provide hints as to what and how. A given corp might be dumping illegal wastes. Maybe the dump's begun to "leak," causing a rash of magic-related illnesses or toxic spirits. Nature spirits and AmerInds could balk at the desecration of their natural lands. Et cetera.
Just a thought. The book was fairly good, too.