Here is a copy of the 400 BP character built on the Character Generator (the one linked in my signature).
I think a mystic adept is the best route to go. 2 points on sorcery/conjuring, 3 points on Phys Adept powers.
For adept powers, get Combat Sense 3, increased pistols 1 and Improved Physical Skill Dodge 2
Spellcasting of 4, specialized in Manipulation Spells.
Pistols of 4, specialized in Heavy Pistols.
Dodge of 6
Summoning of 2 Specialized in air spirits (for increased movement, used when fleeing while screaming like a woman)
Unarmed 1
Body 3
Reaction 5
Agility 4
Strength 3
Charisma 3
Intuition 4
Logic 3
Willpower 3
Edge 4
Magic maxed (5, due to essence loss)
Knowledge skills: Crazy Dancing of 4
Spells: Increase Reflexes
Deflect
Combat Sense
Sustaining foci force 3, used to sustain Increased Reflexes
Sustaining foci force 3, used to sustain Combat Sense
At the beginning of every run, cast Combat Sense force 3 into the sustaining foci, then use Edge to reroll failures and use the successes to overcast (up to 6 successes total).
To dodge, you will have 8 reaction (5 reaction, +3 for increased reflexes)
Plus your combat sense phys ad power of 3 dice
Plus your Combat Sense spell (3 dice, or 6 if you used Edge)
Thats 17 base dice for dodge. Whenever you need to reaaaly dodge, you use your 8 dice from dodge skill.
For situations like the first episode, where he was in a bar that was RAZED by gunfire, cast a force 4 Deflect spell, use edge to overcast and sustain it until shooting is over. Should protect you from most blind suppressive fire without even having to dodge.
Get a Used Alphaware Cyberarm. Put a heavy pistol in it. Later when he is an uber elite runner, replace the built in heavy pistol with an energy weapon (Vashes cybergun was energy, right?)
Your primary weapon is a Cavlier Deputy, modded with Custom Grip. You can get a laser sight, although Vash never needed one.
After initiating, get Adept Centering, so you can begin ignoring wound pentalies and sustaining spell penalties. Raise your magic and get your sorcery to 3 (for force 5 and 6 spells when overcasting) and then raise Adept points, spending them on Combat Sense and probably Mystic Armor (he is covered from scars from being shot, suggesting he has lived through being shot alot, so he must be resilient).
Select the flaw Evil Twin and whip up a character sheet for Knives, your evil brother.
Select the Pacifist flaw, because you will fight to defend, but you hate taking lives.
Give the compulsive 10bp flaw, because you compulsively have loud outbursts, hit on any hottie you see, and always have to help women and children in need.
Use your Crazy Dancing knolwedge skill to dance like a fool when dodging, and try and convince people you are just lucky.
Definately get the Distinctive Style flaw, probably Wanted too. You always wear a red lined coat, and never hide your spikey blond hair. Purchase sunglasse with a lightingbolt shape on the side. Get lowlight, vision mag, and smartlink in the goggles for maximum effect.