Only if you don't pull the trigger...
Or if you do, actually. I've done plenty of evolutions where the gun went "bang" once but it was offline of the target and the slide was kept from cycling fully. In a Fucked Up Tangle ™, it's a lot harder than people think to get the room you need to stop what you're doing and slingshot the slide to give that shot another go. Before you go into a talking about the superiority of revolvers in this instance, you can jam them up just as easily by grabbing the cylinder or the hammer if it has one. Strangely enough, fighting over a gun actually sucks worse in real life than it looks like it sucks in the movies.
When your guards start rolling their firearms against the Unarmed or Melee Armed adept specialty in close combat, it tends to go...poorly.