Although it tastes more like White Wolf's World of Darkness,
Underworld had a couple of were-vampires (once through miscegenation and the other time as a human of special ancestry infected / bitten / infused from werewolf and subsequently vampire). Depending on the order you installed patches and the Bloodmoon expansion, Morrowind let you play a were-vampire too.
For human-origin werewolves in SR I'd still stick with:
QUOTE (BIG BAD BEESTE @ Nov 28 2008, 12:15 PM)

As for using a lycanthropy disease, well HMHVV would be the most likely candidate as a magical virus, and when the Loup-Garou was published in Paranormal Animals of North America that pretty much covered the vacancy with Strain II. Even if it wasn't totally confirmed as rules stating "These are werewolves" it certainly worked in "fluff" and left it up to your GM to decide on the truth of the matter. (Just like Sprites from PAoE are in fact Windlings from the fourth World.)