I'm not an insider so take with a pinch of salt.
The game Equinox was, as far as I know, originally touted as "Shadowrun in the Eighth Age" or something similar. Whatever happened (or didn't) Equinox by "Vagrant Games" is a real "numbers filed off" for Shadowrun in the future. It's basically a love child of the concepts of Shadowrun merged with the premises from Earthdawn.
For those that are not aware of the game, it has some really cool implications that if you're a really Shadowrun-head you might find some gold in.
One of those is that the magical field of a world varies for each world. The cycle of magic is pretty much universal, but not all worlds are cycling lock step. Earth can be in a 6th World-type situation, while another world can be experiencing a 3rd World-no magic thingy.
This variation in the magical field means that metahumans express differently on different worlds. Equinox aggregates this by system, but it also talks about different places within a system where the magical field can produce different results. You're a "beautiful" elf on Earth, but go to another world and you've got fully black eyes and your ears might look more like "vampire" ears (or whatever).
All of this smacks that the universe, like Shadowrun's Earth is full of magical variation, elemental correspondence etc.
Speculate with me. Have fun with it. If it turns your stomach (as I suspect it will with some members [and that's fair enough!]), then turn your eye.