IMO, the level of space development discussed in Target: Wastelands is adequate for the Shadowrun setting (where a rare runner might make a once-in-a-career run in orbit). Actually, the level displayed in T:WL is overly optimistic but, hey, it's meant to be playable and interesting, so I don't mind needing to suspend my disbelief a bit.

Cyberpunk 2020 does alright with space travel from a cyberpunk perspective.

In fact, space power is one of the many factors involved in creating a dark and gritty environment, at least in the US. The EU's (or is it EEC in C2020?) grip on the high frontier has given it a tangible edge over the US, enabling it to use mass driver strikes with some impunity against the US. Some flattened cities and government facilities didn't exactly help the US recover from its uber-depression in C2020.

I'm sure with careful handling, additional space travel in SR wouldn't hurt the setting, but could actually reinforce it.

Yep. And supposedly, "Soldier," with Kurt Russel, was meant to be in the same setting as Bladerunner. For whatever reason, the connection was never developed when the movie rolled into production.

Another excellent sci-fi movie for extending cyberpunk into space is Outland, with Sean Connery. It's set on a very gritty and realistic mining operation (on Io), that's basically a company town operation (hello, megacorps) where the managers are turning a blind eye to a profitable drug trade. The drug in question bakes the brains of its users after about a year, but in the mean time, it really cranks up their productivity, hence the managers don't mind it (very cyberpunk). Arguably, the movie does focus on a shadowrun as seen from "the other side," that of the marshall (Connery) fighting for his life against a hit squad (runners) sent to re-open the drug trade that Connery squashed. Aside from the unrealistic (but entertaining) explosions of people exposed to a vacuum, the science and technology are pretty realistic. Most of the fighting is done with plain old hunting rifles and shotguns, not a ray gun to be found.

Transhuman Space has cyber (well, bio and genetech mostly), but not so much punk. Standards of living tend to be high except in some Third World countries, and many nations that have low standards of living relative to other TSH nations have better standards of living than in the modern US. Megacorps are also not portrayed as behind-the-scenes rulers, though they have their influence.

In short, you can find gritty, edgy places in Transhuman Space, but I don't think I could call the setting cyberpunk as a whole.

Ah, okay....well, as I said, I don't have the book yet (hopefully it will get here before I go to Boston on Thursday). Still, I'm sure Shadowrun could be run just as well with offworld travel being more commonplace.