My personal views on this...
Infected: No... just no. If people want to play vamps, I have run several very good V:tM campaigns in the past. I even have V:tR, though I haven't run it yet. One of the best characters in any of my games was from V:tM. He was a Malki named "Iron Heart" whos insanity was that he throught he was a Mortal Combat character. Sounds pretty funny right? At times it was... but mostly it was freaking scary crazy psycho shiz. Anyway, as I was saying, you want Vamps play a vamp game.
Drakes: Not that I dislike them, but as a PC they just don't really work. If you want to play something like this then I would suggest Fireborn. It does the job many many times better then trying to fit a Drake into a SR4 game. Now as NPCs that fit into the plot, they work well. I got an NPC with latent Drake and Adept. I'll be using him to draw the PCs into a little metaplot with Ghostdancer.
TMs: Ehhhh... I rather dislike some parts of their fluff, but as PCs they are perfectly acceptable and not overpowering (as long as I completely block their access to all that world breaking fluffy stuff, which as a GM I can do and still be RAW).
AI & Freespirits: I like having the rules, since it makes it easier for me as a GM to create them. However, they don't really appear to work well as a character.