So, yet another question. If you play that you have to pay back the karma for a quality, and play it by the book that you have to pay it back as soon as possible (No long term pay it back over the next 60 runs plan or anything similar), would you ever get the quality? It gets you a few extra BP that you could get via other means and some nuyen, but in exchange your character doesn't improve for the first 10-15 runs and doesn't make money for a while either.
Personal opinion. If a player took this negative quality in a game I was running, I would actually prefer they do not every pay off the In Debt Negative Quality. This quality is an essential part of many story motifs in noir. It represents the character's always owing something to somebody for whatever reason. Being beholden to someone and the actions to work around that are an essential part of character motivation and story. Han Solo was In Debt. Tom Regan in Miller's Crossing was always In Debt. It's a classic trope. Makes a powerful tool to have a character make a Run they might not normally take. Characters that drive plot always get more karma.