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I mean, if we assume continued progression of LGBT activism, chances are it's accepted most places, but to what extent? What about the traditional Yakuza? What about the conservative CAS? In fact, due to the lack of a more liberal federal government, the CAS might actually have regressed.
It varies by region, state, or corp. According to the Sprawl Survival Guide, the best source so far, homosexuality is pretty much tolerated in Western countries like the UCAS, Northern Europe, and California, as well as the NAN. It's a contentious issue in Japan (meaning it's DADT), with Shiawase being tenatively anti-and MCT being tenatively pro-marriage (as per Corp Guide). Horizon is, of course, all the pansexuality all the way.
The CAS, which rarely gets talked about in SR in general, is pretty much a blank slate in that regard, excpept vague hints that it is more conservative than the UCAS. That can mean anthing from Clinton-era DADT to Putinism (including moderate persecution of homosexuals) to the theocratic populist dictatorship Cruz stands for, complete with burning Awakened at the stake and homosexuals being hunted and herded into PAB-based clinics to be remade into proper Christians, much like the German pocket theocracy around Munster (not a good place to be meta, gay or female either, btw). YMMV.
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I have no idea how you got the idea that ladyparts cost more from that, but I'm curious!
Reproductive replacement, pp 118 Chrome Flesh. Compare with Sex Change (p 107) and Cyber Genitalia (pp 73).
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discrimination in Shadowrun seems to have taken another classic way of crackpots and fearmongers -- Simply reuse the old boilerplate ideologies with new enemies:
That depends. An Ute indian or Runenthing druid will go by the old races, while America seems to have shifted towards metas, since in SR, most non-white Americans (Latinos and anyone with measurable indigenous roots, which arguably includes most African Americans and solves the population problem the NAN pose otherwise) emigrated into the newly created tribal lands or Aztlan. Aztlaners, on the other hand, probably hate Gringo norms more than Atlaner trolls, given continuous activity by Texan terrorists (or, if you prefer, freedom fighters) that certainly is exploitd to the last by Atlan's media empire.
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rather like Nazi Germany was anti-homosexual
Interestingly, they were entirely anti-gay; much like Victorian England, female homosexuality just never occurred to them and thus, was petty much unpersecuted.
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For example, I remember a Cyberpunk 2020 supplement about a Solo's bar, and the bartender (or was it the owner?) was married to a transgender woman. And that was published in the early 90's.
Ah yeah, Tales from the Forlorn Hope, 1992. That's still a pretty decent campaign book.