(Disclaimer1: Obviously non-canon ideas. I'm sure some people will hate them, but it's something I've been pondering for a couple of days, and I thought I'd share it.)
(Disclaimer2: I haven't seriously read the rules for Infected PCs. I gather they're peculiar; I don't care.)
Vampires have hired "scientists" to study if vampires can survive indefinitely from synthetic/animal nutrition. The studies suggest they can. The vampires make enough campaign donations and finance enough professorships, to keep this going. Of course the whole thing stinks; just like shadowrunners think Aztechnology stinks, this whole scientific "proof"
is as believable as smoking not being bad for you.In practice, vampires just take some people from the Barrens who won't be missed, and after topping up their Essence, throw the remains in the Soylent Food machine. If a vampire gets caught, the rest of the vampires publicly distance themselves, the sucker goes to trial, and may even get convicted (although vampires tend to have good lawyers). Now and then they intentionally create a spare fledgeling vampire to be sacrificed this way, just to pretend to the public that the State really protects the people from rogue vampires.
The whole thing smacks of hypocrisy; that's intentional. Vampires are pretty rare, wealthy and influential. Their main job in the campaign is to show off that society is hopelessly corrupt, that
obviously evil people can get away with it.
And yeah, there are vampire hunter groups. They take down vampires from time to time; that's doable. Of course, the State is obliged to investigate such "murders", although a lot of unhappy investigators drag their feet and secretly sympathize with the vampire hunters. So the vampires hire shadowrunners to take down the vampire hunters (and the vampire hunters may earn their keep as shadowrunners...)
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Yeah, I like vampires. I don't like ghouls so much. This whole drive to humanize them doesn't work on me. While vampires are about Hypocrisy, Monsters Looking Like Us, ghouls are degenerate. They're only vaguely human, can't really hope to masquerade. Their existence sucks; dangerous, but also quite vulnerable.
Ghouls are a plague. They aren't really fit to survive for long, but the pandemic is impossible to contain. It just keeps spreading, and the extermination efforts can't really keep up. If their population gets out of control in the Barrens, then the State will burn them out, but the infection always pops up in a new place.
Ghouls are tragic: they've become monsters that don't have long to live, but will probably cause a lot of harm before someone kills them. The most merciful thing to do is put Ex-Ex between their eyes as fast as possible, from a safe distance.